L-cis-Diltiazem, cyclic nucleotide-gated channel blocker (ab120532)
Key features and details
- Selective cyclic nucleotide-gated channel blocker
- CAS Number: 42399-54-2
- Purity: > 97%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
L-cis-Diltiazem, cyclic nucleotide-gated channel blocker -
Description
Selective cyclic nucleotide-gated channel blocker -
Biological description
Selective inhibitor of cyclic nucleotide-gated (CNG) channels. Blocks rod-type CNGA1, olfactory-type CNGA2 and cone-type CNGA3, at micromolar concentrations. Optical isomer of diltiazem (ab120260). Protects against myocardial dysfunction in vitro.
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Purity
> 97% -
CAS Number
42399-54-2 -
Chemical structure
Properties
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Chemical name
(2R,3R)-(-)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride -
Molecular weight
450.98 -
Molecular formula
C22H26N2O4S.HCl -
PubChem identifier
198106 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=O)O[C@H]1[C@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl -
Source
Synthetic
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Research areas
