KW2449 (ab273596)
Key features and details
- Inhibits FLT3, ABL, and Aurora kinases
- CAS Number: 1000669-72-6
- Purity: > 98%
Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
KW2449 -
Description
Inhibits FLT3, ABL, and Aurora kinases -
Biological description
Multi targeted inhibitor of FLT3 ( with an IC50 of 6.6nM), ABL, ABL-T315I, and Aurora kinase. Tumor growth inhibition in FLT3-mutated xenograft model in vitro. Shows a potent and significant antitumor effect in a dose-dependent manner in MOLM-13 tumour xenograft model in vivo.
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Purity
> 98% -
CAS Number
1000669-72-6 -
Chemical structure
Properties
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Chemical name
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
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Molecular weight
332.40 -
Molecular formula
C20H20N4O -
PubChem identifier
11427553 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 50 mM
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Handling
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CN(CCN1)C(=O)C2=CC=C(C=C2)/C=C/C3=NNC4=CC=CC=C43 -
Source
Synthetic
Images
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Chemical Structure - KW2449 (ab273596)
Chemical structure of KW2449, 1000669-72-6