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Ko-143, BCRP inhibitor (ab146198)

Price and availability

93 811 ₸

Availability

Order now and get it on Friday February 26, 2021

Key features and details

  • Potent, selective BCRP inhibitor
  • CAS Number: 461054-93-3
  • Soluble in ethanol to 100 mM and in DMSO to 50 mM
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    Ko-143, BCRP inhibitor
  • Description

    Potent, selective BCRP inhibitor
  • Biological description

    Potent, selective BCRP inhibitor (EC50 values are 23 and 26 nM respectively for the export of mitoxantrone (ab145668, ab141041) and topotecan (ab120388) in cancer cell lines). Non-toxic fumitremorgin C (ab144258) analog. Shows chemopotentiating effects in vivo.
  • CAS Number

    461054-93-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester
  • Molecular weight

    469.57
  • Molecular formula

    C26H35N3O5
  • PubChem identifier

    10322450
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)C[C@H]1C2=C(C[C@@H]3N1C(=O)[C@@H](NC3=O)CCC(=O)OC(C)(C)C)C4=C(N2)C=C(C=C4)OC
  • Source

    Synthetic

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    • Tags & Cell Markers
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    • New
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    • Transporters
    • ABC transporter

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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