Kifunensine, class I alpha-mannosidase inhibitor (ab215116)
Key features and details
- Cell-permeable, potent, selective class I α-mannosidase inhibitor
- CAS Number: 109944-15-2
Soluble in water to 10 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Kifunensine, class I alpha-mannosidase inhibitor -
Description
Cell-permeable, potent, selective class I α-mannosidase inhibitor -
Alternative names
- FR 900494
- Hexahydro-6R,7S,8aS-trihydroxy-5R-(hydroxymethyl)-imidazo[1,2-a] pyridine-2,3-dione
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Biological description
Cell-permeable, potent, selective inhibitor of class I α-mannosidases. (IC50 = 20-50 nM for mung bean α-1,2-mannosidase I). Alkaloid originally isolated from the actinomycete Kitasatosporia kifunense. Used to suppress Endoplasmic Reticulum-Associated Degradation (ERAD) via the inhibition of endoplasmic reticulum-associated mannosidase activity.
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CAS Number
109944-15-2 -
Chemical structure
Properties
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Chemical name
(5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)imidazo[1,2-a]pyridine-2,3-dione
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Molecular weight
232.19 -
Molecular formula
C812N2O6 -
PubChem identifier
130611 -
Storage instructions
Shipped at Room Temperature. Store at -20°C long term. Store under desiccating conditions. -
Solubility overview
Soluble in water to 10 mM (with warming)
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C([C@@H]1[C@H]([C@@H]([C@@H]([C@@H]2N1C(=O)C(=O)N2)O)O)O)O -
Source
Synthetic
