K252a, protein and CAM kinase inhibitor (ab120419)
Key features and details
- Highly potent inhibitor of protein and CAM kinases
- CAS Number: 99533-80-9
- Purity: > 99%
- Soluble in DMSO to 25 mM and in ethanol to 5 mM
- Form / State: Solid
- Source: Nocardiopsis sp.
Overview
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Product name
K252a, protein and CAM kinase inhibitor -
Description
Highly potent inhibitor of protein and CAM kinases -
Biological description
Highly potent, cell-permeable inhibitor of protein kinases such as PKA, PKC, PKG (IC50 = 18-25 nM), Serine/threonine protein kinases (IC50 values are 10-20 nM) and CAM kinase II (Ki = 1.8 nM). Analog of staurosporine (ab120056), exhibits a wide range of effects including neuroprotection and improvement of psoriasis in vivo.
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Purity
> 99% -
CAS Number
99533-80-9 -
Chemical structure
Properties
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Chemical name
(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester -
Molecular weight
467.48 -
Molecular formula
C27H21N3O5 -
PubChem identifier
3035817 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM and in ethanol to 5 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(OC)[C@@]8(O)C[C@H]7O[C@]8(C)n4c3c1n7c6ccccc6c1c2c(CNC2=O)c3c5ccccc45 -
Source
Nocardiopsis sp.
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Research areas
