K 41498, CRF2 antagonist (ab141002)
Key features and details
- Potent, highly selective CRF2 antagonist
- CAS Number: 434938-41-7
- Purity: > 98%
- Soluble in water
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
K 41498, CRF2 antagonist -
Description
Potent, highly selective CRF2 antagonist -
Biological description
Potent and highly selective CRF2 antagonist (Ki values are 0.66, 0.62 and 425 nM at CRF2α,CRF2β and CRF1, respectively). Inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells in vitro. Able to block hypotension induced by urocortin following systemic administration.
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Purity
> 98% -
CAS Number
434938-41-7 -
Chemical structure
Properties
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Molecular weight
3632.22 -
Molecular formula
C162H276N48O46 -
Sequence
FHLLRKXIEIEKQEKEKQQAANNRLLLDTI (Modifications: C-terminal amide; X-7 = Nle; Phe-1 = D-Phe) -
PubChem identifier
16132335 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
