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Ispinesib (SB-715992) (ab273521)

Key features and details

  • Potent, selective and reversible allosteric inhibitor of KSP
  • CAS Number: 336113-53-2
  • Purity: > 98%

  • Soluble in DMSO to 50 mM and ethanol to 100 mM

  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    Ispinesib (SB-715992)

  • Description

    Potent, selective and reversible allosteric inhibitor of KSP

  • Alternative names

    • SB-715992

  • Biological description

    A potent, selective and reversible allosteric inhibitor of KSP with IC50 value of 0.5 nM. Often combines with chemotherapy drugs to tumor treatment.

  • Purity

    > 98%

  • CAS Number

    336113-53-2

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2- quinazolinyl]-2-methylpropyl]-4-methylbenzamide

  • Molecular weight

    517.06

  • Molecular formula

    C30H33ClN4O2

  • PubChem identifier

    6851740

  • Storage instructions

    Shipped at 4°C. Store at -20°C.

  • Solubility overview

    Soluble in DMSO to 50 mM and ethanol to 100 mM

  • Handling

    Refer to SDS for further information

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC=C(C=C1)C(=O)N(CCCN)[C@@H](C2=NC3=C(C=CC(=C3)Cl)C(=O)N2CC4=CC=CC=C4)C(C)C

  • Source

    Synthetic

Images

  • Chemical Structure - Ispinesib (SB-715992) (ab273521)
    Chemical Structure - Ispinesib (SB-715992) (ab273521)

    Chemical structure of Ispinesib (SB-715992), 336113-53-2

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