ICA-27243, KV7.2 and KV7.3 K+ channel opener (ab145545)
Key features and details
- Potent, selective KV7.2 and KV7.3 K+ channel opener
- CAS Number:
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
ICA-27243, KV7.2 and KV7.3 K+ channel opener -
Description
Potent, selective KV7.2 and KV7.3 K+ channel opener -
Biological description
Potent, selective KV7.2 and KV7.3 K+ channel opener (EC50 values are 0.4 and 9.7 and >30 μM for KCNQ2/3, KCNQ4 and KCNQ5 respectively). Shows antidyskinetic, anticonvulsant and antinociceptive effects in vivo. Orally active. -
Purity
> 99% -
Chemical structure
Properties
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Chemical name
N-(6-Chloropyridin-3-yl)-3,4-difluorobenzamide -
Molecular weight
268.65 -
Molecular formula
C12H7ClF2N2O -
PubChem identifier
9903497 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC(=C(C=C1C(=O)NC2=CN=C(C=C2)Cl)F)F -
Source
Synthetic
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Research areas
