Ibudilast, PDE inhibitor (ab143333)
Key features and details
- Non-selective PDE inhibitor. Anti-inflammatory agent.
- CAS Number: 50847-11-5
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ibudilast, PDE inhibitor -
Description
Non-selective PDE inhibitor. Anti-inflammatory agent. -
Biological description
Non-selective PDE inhibitor (IC50 values are 53, 35, 48, 12 and 10 μM for PDE Ia, II, III, IV and V respectively). Anti-inflammatory agent. Inhibits platelet aggregation. Centrally active via glial cell attenuation. Shows bronchodilatory, vasodilatory and neuroprotective effects in vivo. Orally active. Blood-brain barrier permeable.
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Purity
> 98% -
CAS Number
50847-11-5 -
Chemical structure
Properties
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Chemical name
2-Methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one -
Molecular weight
230.31 -
Molecular formula
C14H18N2O -
PubChem identifier
3671 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)C1=NN2C=CC=CC2=C1C(=O)C(C)C -
Source
Synthetic
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Research areas
