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Human Mannan Binding Lectin/MBL peptide (237-248) (Carboxyterminal end) (ab45655)

Key features and details

  • Suitable for: Blocking

Description

  • Product name

    Human Mannan Binding Lectin/MBL peptide (237-248) (Carboxyterminal end)
    See all Mannan Binding Lectin/MBL proteins and peptides

  • Animal free

    No

  • Nature

    Synthetic

    • Species

      Human

    • Sequence

      STSHLAVCEFPI

    • Amino acids

      237 to 248

  • Description

    Human Mannan Binding Lectin/MBL peptide

Preparation and Storage

  • Alternative names

    • COLEC 1
    • COLEC1
    • Collectin-1
    • HSMBPC
    • Lectin, mannose-binding, soluble, 2
    • Mannan binding lectin
    • Mannan binding protein
    • Mannan-binding protein
    • Mannose binding lectin
    • Mannose binding lectin (protein C) 2 soluble
    • Mannose binding lectin (protein C) 2, soluble
    • Mannose binding lectin (protein C) 2, soluble (opsonic defect)
    • Mannose binding lectin 2 soluble
    • Mannose binding lectin 2, soluble (opsonic defect)
    • Mannose binding lectin protein C2 soluble opsonic defect
    • Mannose binding protein
    • Mannose binding protein C
    • Mannose binding protein C precursor
    • Mannose binding protein, serum
    • Mannose-binding lectin
    • Mannose-binding protein C
    • MBL
    • MBL 2
    • MBL2
    • MBL2_HUMAN
    • MBL2D
    • MBP
    • MBP 1
    • MBP C
    • MBP-C
    • MBP1
    • MBPB
    • MBPC
    • MBPD
    • MGC116832
    • MGC116833
    • Opsonic defect
    • protein C
    • Soluble mannose binding lectin
    see all

  • Function

    Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.

  • Tissue specificity

    Plasma protein produced mainly in the liver.

  • Involvement in disease

    Note=There is an association between low levels of MBL2 and a defect of opsonization which results in susceptibility to frequent and chronic infections.

  • Sequence similarities

    Contains 1 C-type lectin domain.
    Contains 1 collagen-like domain.

  • Cellular localization

    Secreted.
  • Information by UniProt

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