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Recombinant Human Mannan Binding Lectin/MBL protein (ab151947)

Key features and details

  • Expression system: HEK 293 cells
  • Purity: > 95% SDS-PAGE
  • Endotoxin level:
  • Tags: His tag C-Terminus
  • Suitable for: SDS-PAGE, HPLC

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -80°C.

    pH: 7.20
    Constituents: 94% Phosphate Buffer, 5% Trehalose, 0.88% Sodium chloride

  • Reconstitution
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at

    General Info

    • Alternative names

      • COLEC 1
      • COLEC1
      • Collectin-1
      • HSMBPC
      • Lectin, mannose-binding, soluble, 2
      • Mannan binding lectin
      • Mannan binding protein
      • Mannan-binding protein
      • Mannose binding lectin
      • Mannose binding lectin (protein C) 2 soluble
      • Mannose binding lectin (protein C) 2, soluble
      • Mannose binding lectin (protein C) 2, soluble (opsonic defect)
      • Mannose binding lectin 2 soluble
      • Mannose binding lectin 2, soluble (opsonic defect)
      • Mannose binding lectin protein C2 soluble opsonic defect
      • Mannose binding protein
      • Mannose binding protein C
      • Mannose binding protein C precursor
      • Mannose binding protein, serum
      • Mannose-binding lectin
      • Mannose-binding protein C
      • MBL
      • MBL 2
      • MBL2
      • MBL2_HUMAN
      • MBL2D
      • MBP
      • MBP 1
      • MBP C
      • MBP-C
      • MBP1
      • MBPB
      • MBPC
      • MBPD
      • MGC116832
      • MGC116833
      • Opsonic defect
      • protein C
      • Soluble mannose binding lectin
      see all

    • Function

      Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.

    • Tissue specificity

      Plasma protein produced mainly in the liver.

    • Involvement in disease

      Note=There is an association between low levels of MBL2 and a defect of opsonization which results in susceptibility to frequent and chronic infections.

    • Sequence similarities

      Contains 1 C-type lectin domain.
      Contains 1 collagen-like domain.

    • Cellular localization

      Secreted.
    • Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

References (0)

Publishing research using ab151947? Please let us know so that we can cite the reference in this datasheet.

ab151947 has not yet been referenced specifically in any publications.

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