Herkinorin, mu opioid agonist (ab120147)
Key features and details
- Non-internalising μ opioid agonist
- CAS Number: 862073-77-6
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Herkinorin, mu opioid agonist -
Description
Non-internalising μ opioid agonist -
Biological description
Selective μ opioid receptor agonist derived from the plant product, salvinorin A (ab120084). Does not promote the recruitment of beta-arrestin-2 or lead to receptor internalization.
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Purity
> 98% -
CAS Number
862073-77-6 -
Chemical structure
Properties
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Chemical name
(2S,4aR,6aR,7R,9S,10aS,10bR)-Methyl 9-(benzoyloxy)-2-(furan-3-yl)-dodecahydro-6a,10b-dimethyl-4,10-dioxo-1H-benzo[f]isochromene-7-carboxylate -
Molecular weight
494.53 -
Molecular formula
C28H30O8 -
PubChem identifier
11431898 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(OC)[C@@H]5C[C@H](OC(=O)c1ccccc1)C(=O)[C@H]2[C@@]5(C)CC[C@H]3C(=O)O[C@@H](C[C@]23C)c4ccoc4 -
Source
Synthetic
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Research areas
Images
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Immunocytochemistry/ Immunofluorescence - Herkinorin, mu opioid agonist (ab120147) Image from Rowan, Matthew P et al., PLOS One., 9(4): e93688. Fig 1 A and D.; doi: 10.1371/journal.pone.0093688 Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/
Primary sensory neurons treated with vehicle (0.1% DMSO) (top panel) and 10 μM of ab120147 for 15 minutes (bottom panel) revealed no significant difference in CFP emission. It does not recruit β-arrestin2 to MOPr in primary sensory neurons.
