H 1152 dihydrochloride, ROCK inhibitor (ab254521)
Key features and details
- Highly specific and potent ROCK inhibitor
- CAS Number: 871543-07-6
Soluble in methanol and water.
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
H 1152 dihydrochloride, ROCK inhibitor -
Description
Highly specific and potent ROCK inhibitor -
Alternative names
- H1152
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Biological description
Highly specific, potent, cell permeable and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Cell-permeable isoquinolinesulfonamide compound. Exhibits a much weaker affinity for other serine/threonine kinases (Ki=630nM for PKA 9.27mM for PKC, and 10.1mM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50=2.5nM) in NT-2 cells.
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General notes
Hygroscopic. Store under inert atmosphere.
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CAS Number
871543-07-6 -
Chemical structure
Properties
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Chemical name
4-Methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline dihydrochloride
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Molecular weight
392.34 -
Molecular formula
C16H23Cl2N3O2S -
PubChem identifier
11560225 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in methanol and water.
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Handling
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@H]1CNCCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)C.Cl.Cl -
Source
Synthetic
