GW-441756 hydrochloride, TrKA receptor tyrosine kinase inhibitor (ab141051)
Key features and details
- Potent, selective TrKA receptor tyrosine kinase inhibitor
- CAS Number: 504433-23-2
- Purity: > 99%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
GW-441756 hydrochloride, TrKA receptor tyrosine kinase inhibitor -
Description
Potent, selective TrKA receptor tyrosine kinase inhibitor -
Biological description
Potent, selective TrKA tyrosine kinase inhibitor (IC50 = 2 nM). Displays >100-fold selectivity over a range of other kinases. Antineoplastic effects.
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Purity
> 99% -
CAS Number
504433-23-2 -
Chemical structure
Properties
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Chemical name
1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one hydrochloride -
Molecular weight
311.77 -
Molecular formula
C17H13N3O.HCl -
PubChem identifier
9943465 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.O=C4Nc1cccnc1\C4=C\c3cn(C)c2ccccc23 -
Source
Synthetic
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Research areas
