GDC0879 (ab273489)
Key features and details
- Potent and selective B-Raf inhibitor
- CAS Number: 905281-76-7
- Purity: > 98%
Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
GDC0879 -
Description
Potent and selective B-Raf inhibitor -
Biological description
Potent and selective B-Raf inhibitor (IC50 = 0.13 nM against purified V600E enzyme). Inhibits cellular pERK (IC50 = 63 nM). Blocks Raf/MEK/ERK signaling in B-Raf V600E mutant cell lines. Highly selective against a panel of 140 full-length protein kinases.
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Purity
> 98% -
General notes
For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.
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CAS Number
905281-76-7 -
Chemical structure
Properties
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Chemical name
5-[1-(2-Hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-dihydroinden-1-one oxime
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Molecular weight
334.37 -
Molecular formula
C19H18N4O2 -
PubChem identifier
11717001 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 50 mM
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Handling
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1C/C(=N\O)/C2=C1C=C(C=C2)C3=CN(N=C3C4=CC=NC=C4)CCO -
Source
Synthetic
Images
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Chemical Structure - GDC0879 (ab273489)
Chemical structure of GDC0879, 905281-76-7
