Felodipine, L-type Ca2+ channel blocker (ab141797)
Key features and details
- Selective L-type Ca2+ channel blocker
- CAS Number: 72509-76-3
- Purity: > 99%
- Soluble in DMSO 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Felodipine, L-type Ca2+ channel blocker -
Description
Selective L-type Ca2+ channel blocker -
Biological description
Selective L-type Ca2+ channel blocker. Selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity and shows antihypertensive effects in vivo. Orally active. -
Purity
> 99% -
CAS Number
72509-76-3 -
Chemical structure
Properties
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Chemical name
5-O-Ethyl 3-O-methyl-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate -
Molecular weight
384.25 -
Molecular formula
C18H19Cl2NO4 -
PubChem identifier
3333 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C -
Source
Synthetic
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Research areas
Images
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Functional Studies - Felodipine, L-type Ca2+ channel blocker (ab141797)Felodipine blocks L-type Ca2+ currents in Xenopus oocytes.
Superimposed current traces of L-type channels (CaV1.2+a2d1+ß1a), before and during applications of 1 and 10 µM Felodipine (ab141797) as indicated on the left. Holding potential was -100 mV and currents were elicited every 10 seconds by 100 ms steps to +10 mV.
