Febuxostat, non-purine xanthine oxidase inhibitor (ab143619)
Key features and details
- Highly potent, selective, non-competitive, non-purine xanthine oxidase inhibitor
- CAS Number: 144060-53-7
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Febuxostat, non-purine xanthine oxidase inhibitor -
Description
Highly potent, selective, non-competitive, non-purine xanthine oxidase inhibitor -
Biological description
Highly potent, selective, non-competitive, non-purine xanthine oxidase inhibitor (Ki = 0.6 nM). Inhibits xanthine dehydrogenase. Reduces uric acid and ROS levels. Shows antihyperuricemic, anti-ischemic, cardioprotective and renoprotective effects in vivo. Orally active. -
Purity
> 98% -
CAS Number
144060-53-7 -
Chemical structure
Properties
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Chemical name
2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid -
Molecular weight
316.37 -
Molecular formula
C16H16N2O3S -
PubChem identifier
134018 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(SC(=N1)C2=CC(=C(C=C2)OCC(C)C)C#N)C(=O)O -
Source
Synthetic
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Research areas
- Epigenetics and Nuclear Signaling
- Transcription
- Domain Families
- HLH / Leucine Zipper
- Helix-Turn-Helix
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Retinoic & Retinoid
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
- Epigenetics and Nuclear Signaling
- Chromatin Modifying Enzymes
- Acetylation
- HDACs
- Class II / Hda1 Class
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
