EPPTB, TAAR1 antagonist (ab254331)
Key features and details
- Novel, selective, highly potent TAAR1 antagonist
- CAS Number: 1110781-88-8
- Purity: > 99%
Soluble in DMSO to 50mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
EPPTB, TAAR1 antagonist -
Description
Novel, selective, highly potent TAAR1 antagonist -
Biological description
Novel, selective, highly potent trace amine associated receptor 1 (TAAR1) antagonist. Higher potency in mouse than rat and human (IC50 values are 28nM, 4539nM and 7487nM, respectively). Increases firing frequency of dopamine (DA)neurons in ventral tegmental area by blocking inward potassium current mediated by TAAR1, increasing DA activity on D2 receptor. Displays inverse agonism in vitro by reducing cAMP levels (IC50 =19nM).
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Purity
> 99% -
General notes
Solutions in DMSO may be stored at -20°C for up to 3 months.
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CAS Number
1110781-88-8 -
Chemical structure
Properties
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Chemical name
N-(3-Ethoxyphenyl)-4-pyrrolidin-1-yl-3-(trifluoromethyl)benzamide
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Molecular weight
378.39 -
Molecular formula
C20H21F3N2O2 -
PubChem identifier
25175634 -
Storage instructions
Shipped at Room Temperature. Store at Room Temperature. Store at -20°C. Please see notes section. -
Solubility overview
Soluble in DMSO to 50mM
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Handling
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCOC1=CC=CC(=C1)NC(=O)C2=CC(=C(C=C2)N3CCCC3)C(F)(F)F -
Source
Synthetic
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Research areas