E-64, cysteine protease inhibitor (ab141418)
Key features and details
- Irreversible, selective, potent cysteine protease inhibitor
- CAS Number: 66701-25-5
- Purity: > 99%
- Soluble in water to 50 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
E-64, cysteine protease inhibitor -
Description
Irreversible, selective, potent cysteine protease inhibitor -
Alternative names
- 1-trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane
- L-trans-3-Carboxyoxiran-2-carbonyl-L-leucylagmatine
- N-(trans-Epoxysuccinyl)-L-leucine 4-guanidinobutylamide
- trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane
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Biological description
Irreversible, potent, and selective cysteine protease inhibitor (IC50 values for cathepsins K, S, and L, in vitro, are 1.4, 4.1, and 2.5 nM, respectively). Does not inhibit serine proteases (except trypsin).
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Purity
> 99% -
CAS Number
66701-25-5 -
Chemical structure
Properties
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Chemical name
(2R,3R)-3-[[(2S)-1-[4-(Diaminomethylideneamino)butylamino]-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid -
Molecular weight
357.41 -
Molecular formula
C15H27N5O5 -
PubChem identifier
439487 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 50 mM and in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)CC(C(=O)NCCCCN=C(N)N)NC(=O)C1C(O1)C(=O)O -
Source
Synthetic
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Research areas
