Dimebon dihydrochloride (ab254225)
Key features and details
- Activator of AMPK, potentiator of AMPA, inhibitor of L-type voltage-gated Ca2+ channels, NMDA, H1/2 histamine, α-adrenergic and 5-HT2C/5A/6 receptors
- CAS Number: 97657-92-6
- Purity: > 98%
Soluble in water to 25mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Dimebon dihydrochloride -
Description
Activator of AMPK, potentiator of AMPA, inhibitor of L-type voltage-gated Ca2+ channels, NMDA, H1/2 histamine, α-adrenergic and 5-HT2C/5A/6 receptors -
Alternative names
- Dimebon 2HCl
- Latrepirdine
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Biological description
Activator of AMPK, potentiator of AMPA, and an inhibitor of L-type voltage-gated Ca2+ channels, NMDA receptors, H1/2 histamine receptors, α-adrenergic receptors, and 5-HT2C/5A/6 receptors. Displays neuroprotective and cognition enhancing effects in neurodegenerative diseases and decreases neuronal excitability and glutamate release. In animal models of autotrophic lateral sclerosis (ALS), it delays the onset of symptoms and increases the lifespan. In animal models of Alzheimer’s disease, this compound regulates APP metabolism, decreasing levels of amyloid-β (Aβ). In other animal models, dimebon prevents Aβ-induced mitochondrial swelling in the brain. Exhibits beneficial effects in animal models of Parkinson’s disease.
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Purity
> 98% -
CAS Number
97657-92-6 -
Chemical structure
Properties
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Chemical name
2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride
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Molecular weight
392.37 -
Molecular formula
C21H25N3.2HCl -
PubChem identifier
23729232 -
Storage instructions
Shipped at Room Temperature. Store at -20°C long term. -
Solubility overview
Soluble in water to 25mM
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Handling
Toxic, refer to SDS for further information.
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SMILES
CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CN=C(C=C4)C.Cl.Cl -
Source
Synthetic
