Daphnetin, Protein kinase inhibitor (ab143113)
Key features and details
- Protein kinase inhibitor; EGFR, PKA and PKC
- CAS Number: 486-35-1
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Daphnetin, Protein kinase inhibitor -
Description
Protein kinase inhibitor; EGFR, PKA and PKC -
Biological description
Protein kinase inhibitor (IC50 values are 7.67, 9.33 and 25.01 μM for EGFR, PKA and PKC respectively). Inhibits EGFR competitively to ATP and non-competitively to the peptide substrate. Coumarin (ab142628) derivative. Shows analgesic, antimalarial, antiarthritic, and antipyretic effects in vivo. -
CAS Number
486-35-1 -
Chemical structure
Properties
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Chemical name
7,8-Dihydroxychromen-2-one -
Molecular weight
178.14 -
Molecular formula
C9H6O4 -
PubChem identifier
5280569 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC(=C(C2=C1C=CC(=O)O2)O)O -
Source
Synthetic
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Research areas
