Daclatasvir (BMS-790052), HCV NS5A protein inhibitor (ab231507)
Key features and details
- Potent, direct-acting, small molecule inhibitor of HCV NS5A protein
- CAS Number: 1009119-64-5
- Purity: = 97%
DMSO = 200.3 mM
Ethanol = 200.3 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Daclatasvir (BMS-790052), HCV NS5A protein inhibitor -
Description
Potent, direct-acting, small molecule inhibitor of HCV NS5A protein -
Alternative names
- BMS-790052
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Biological description
Daclatasvir a potent, direct acting, small molecule inhbitor of HCV NS5A protein. It inhbibits replicons expressing a wide range of HCV genotypes with EC50 values in the pM range (9 and 71 pM against the 1b and 2a genotypes, respectively). It also inhibits infection by the JFH-1 genotype 2a virus in cultured cells. Daclatasvir is thought to inhibit relication of the HCV viral genome by affecting the subcellular localization of HCV NS5A and preventing its incorporation into relication complexes. In HCV-infected Huh7 cells, Daclatasvir (1 nM) inhibits viral RNA synthesis and viron assembly. Daclatasvir displays moderate activity against the OAT1B1 (IC50 = 1.5 μM) and OAT1B3 (IC50 = 3.27 μM) organic anion transporters.
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Purity
= 97% -
CAS Number
1009119-64-5 -
Chemical structure
Properties
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Chemical name
Methyl N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
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Molecular weight
738.89 -
Molecular formula
C40H50N8O6 -
PubChem identifier
25154714 -
Storage instructions
Shipped at 4°C. Store at -20°C. -
Solubility overview
DMSO = 200.3 mM
Ethanol = 200.3 mM
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SMILES
CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC -
Source
Synthetic
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Research areas
