Dabrafenib, mutant B-Raf V600E inhibitor (ab222019)
Key features and details
- Potent mutant B-Raf V600E inhibitor
- CAS Number: 1195765-45-7
- Purity: > 98%
- Soluble in DMSO to 50 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Dabrafenib, mutant B-Raf V600E inhibitor -
Description
Potent mutant B-Raf V600E inhibitor -
Alternative names
- GSK2118436
- Tafinlar
-
Biological description
Potent, ATP-competitive mutant B-Raf V600E inhibitor (IC50 = 0.7 nM), with selectivity versus wild-type B-Raf (IC50 = 5.2 nM) and c-RAf (IC50 = 6.3 nM) in cell-free assays. Antitumor activity in vivo in mouse models of B-Raf V600E melanoma.
-
Purity
> 98% -
CAS Number
1195765-45-7 -
Chemical structure
Properties
-
Chemical name
N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide -
Molecular weight
519.56 -
Molecular formula
C23H20F3N5O2S -
PubChem identifier
44462760 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 50 mM (with warming) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F -
Source
Synthetic
-
Research areas
