AS601245, JNK inhibitor (ab145194)
Key features and details
- Potent, selective, ATP competitive JNK inhibitor. Cell-permeable.
- CAS Number: 345987-15-7
- Purity: > 95%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AS601245, JNK inhibitor -
Description
Potent, selective, ATP competitive JNK inhibitor. Cell-permeable. -
Biological description
Potent, selective, ATP competitive JNK inhibitor (IC50 values are 150, 220 and 70 nM for hJNK1,2 and 3 respectively). Reduces cell adhesion and migration in cancer cells. Shows neuroprotective, anti-ischemic effects in vivo. Blood-brain barrier and cell-permeable. -
Purity
> 95% -
CAS Number
345987-15-7 -
Chemical structure
Properties
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Chemical name
(2Z)-2-(3H-1,3-Benzothiazol-2-ylidene)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile -
Molecular weight
372.45 -
Molecular formula
C20H16N6S -
PubChem identifier
11422035 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC=C2C(=C1)N/C(=C(/C#N)\C3=NC(=NC=C3)NCCC4=CN=CC=C4)/S2 -
Source
Synthetic
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Research areas
