CRT0066101, protein kinase D inhibitor (ab144637)
Key features and details
- Potent and selective protein kinase D inhibitor
- CAS Number: 1883545-60-5
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
CRT0066101, protein kinase D inhibitor -
Description
Potent and selective protein kinase D inhibitor -
Biological description
Potent and selective protein kinase D inhibitor (IC50 values are 1, 2 and 2.5 nM at PKD1, PKD3 and PKD2, respectively). Reduces proliferation of pancreatic cancer cells. Orally active. Antitumor agent. Active in vivo and in vitro.
Also available in simple stock solutions (ab146740) - add 1 ml of water to get an exact, ready-to-use concentration. -
Purity
> 99% -
General notes
Sold under license from CRT -
CAS Number
1883545-60-5 -
Chemical structure
Properties
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Chemical name
2-[4-[[(2R)-2-Aminobutyl]amino]pyrimidin-2-yl]-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride -
Molecular weight
411.33 -
Molecular formula
C18H22N6O.2HCl -
PubChem identifier
136664697 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC[C@H](CNC1=NC(=NC=C1)C2=C(C=CC(=C2)C3=CN(N=C3)C)O)N.Cl.Cl -
Source
Synthetic
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Research areas
