Etoposide phosphate, Topoisomerase II inhibitor (ab142426)
Key features and details
- Topoisomerase II inhibitor
- CAS Number: 117091-64-2
- Purity: > 98%
- Soluble in water to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Etoposide phosphate, Topoisomerase II inhibitor -
Description
Topoisomerase II inhibitor -
Biological description
Topoisomerase II inhibitor. Forms ternary complex with DNA and topoisomerase II to prevent re-ligation of DNA strands. Causes errors in DNA synthesis and apoptosis in cancer cells. Increases acetylation of eEF1A. Antitumor agent. Active in vivo and in vitro. -
Purity
> 98% -
CAS Number
117091-64-2 -
Chemical structure
Properties
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Chemical name
[4-[5-[(7,8-Dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy]-8-oxo-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-9-yl]-2,6-dimethoxyphenyl] dihydrogen phosphate -
Molecular weight
668.54 -
Molecular formula
C29H33O16P -
PubChem identifier
16760419 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1OCC2C(O1)C(C(C(O2)OC3C4COC(=O)C4C(C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)OP(=O)(O)O)OC)O)O -
Source
Synthetic
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Research areas