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Biochemicals Product Range New

Concanamycin B, H+-ATPase inhibitor (ab144228)

Key features and details

  • Potent, selective vacuolar type H+-ATPase inhibitor. Antibiotic agent.
  • CAS Number: 81552-33-2
  • Purity: > 98%
  • Soluble in DMSO
  • Form / State: Solid
  • Source: Streptomyces sp.

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Overview

  • Product name

    Concanamycin B, H+-ATPase inhibitor
  • Description

    Potent, selective vacuolar type H+-ATPase inhibitor. Antibiotic agent.
  • Biological description

    Potent, selective vacuolar type H+-ATPase inhibitor. Antibiotic agent. Induces EGF-dependent apoptosis. Shows similar effects as Concanamycin A (ab144227) and Concanamycin C (ab144229). Shows potent antiviral effects (IC50 = 6 nM, HSV-1 replication).
  • Purity

    > 98%
  • CAS Number

    81552-33-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [(2R,3S,4R,6R)-6-[(2R,4R,5S,6R)-2-[(2S,3R,4S)-4-[(2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-10,12-dihydroxy-3,17-dimethoxy-7,9,11,13,15-pentamethyl-18-oxo-1-oxacyclooctadeca-4,6,14,16-tetraen-2-yl]-3-hydroxypentan-2-yl]-2-hydroxy-5-methyl-6-[(E)-prop-1-enyl]oxan-4-yl]oxy-4-hydroxy-2-methyloxan-3-yl] carbamate
  • Molecular weight

    852.06
  • Molecular formula

    C45H73NO14
  • PubChem identifier

    6440685
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C/C=C/[C@@H]1[C@H]([C@@H](C[C@@](O1)([C@@H](C)[C@@H]([C@H](C)[C@@H]2[C@H](/C=C/C=C(/C[C@H]([C@@H]([C@@H]([C@@H]([C@@H](/C=C(/C=C(/C(=O)O2)\OC)\C)C)O)C)O)C)\C)OC)O)O)O[C@H]3C[C@H]([C@@H]([C@H](O3)C)OC(=O)N)O)C
  • Source

    Streptomyces sp.

  • Research areas

    • Biochemicals
    • Product Range
    • New
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Chemical Type
    • Antibiotic
    • Biochemicals
    • Pharmacology
    • Enzymes
    • ATPase & GTPase
    • Inhibitors

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