Lorcainide hydrochloride, Na+/K+ ATPas inhibitor (ab141821)
Key features and details
- Voltage-gated Na+ channel blocker. Inhibits Na+/K+ ATPas.
- CAS Number: 58934-46-6
- Purity: > 99%
- Soluble in water to 50 mM, in DMSO to 50 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Lorcainide hydrochloride, Na+/K+ ATPas inhibitor -
Description
Voltage-gated Na+ channel blocker. Inhibits Na+/K+ ATPas. -
Biological description
Voltage-gated Na+ channel blocker. Inhibits Na+/K+ ATPase (IC50 = 34 μM). Shows anti-arrhythmia and neuroprotective effects in vivo. -
Purity
> 99% -
CAS Number
58934-46-6 -
Chemical structure
Properties
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Chemical name
N-(4-Chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-4-yl)acetamide hydrochloride -
Molecular weight
407.40 -
Molecular formula
C22H27ClN2O.HCl -
PubChem identifier
6917855 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 50 mM, in DMSO to 50 mM and in ethanol to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)N1CCC(CC1)N(C2=CC=C(C=C2)Cl)C(=O)CC3=CC=CC=C3.Cl -
Source
Synthetic
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Research areas
Images
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Functional Studies - Lorcainide hydrochloride, Na+/K+ ATPas inhibitor (ab141821)Lorcainide HCl inhibits NaV1.7 channels expressed in HEK293 cells.
A: Time course of current reversible inhibition by 50 µM Lorcainide HCl (ab141821). Currents were elicited by a voltage ramp from a holding potential of -100 mV to 60 mV (30 ms) delivered every 10 seconds. B: Example traces of current response to voltage ramp stimulation before and during 50 µM Lorcainide HCl application.