QVD-OPh, caspase inhibitor (ab141421)
Key features and details
- Potent, cell-permeable, irreversible broad-spectrum caspase inhibitor
- CAS Number: 1135695-98-5
- Purity: > 95%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
QVD-OPh, caspase inhibitor -
Description
Potent, cell-permeable, irreversible broad-spectrum caspase inhibitor -
Biological description
Potent, cell-permeable, irreversible broad-spectrum caspase inhibitor (IC50 values are 25, 50, 100 and 430 nM for caspase-3, 1, 8 and 9 respectively). Inhibits apoptosis. Shows anti-ischemic and neuroprotective effects in vivo. Blood-brain barrier permeable. -
Purity
> 95% -
CAS Number
1135695-98-5 -
Chemical structure
Properties
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Molecular weight
513.49 -
Molecular formula
C26H25F2N3O6 -
Sequence
VD (Modifications: N-terminal quinolyl; C-terminal OPh) -
PubChem identifier
11237609 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(NC(C(COC1=C(F)C=CC=C1F)=O)CC(O)=O)C(C(C)C)NC(C2=NC3=CC=CC=C3C=C2)=O -
Source
Synthetic
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Research areas
