ALLN (DMSO solution), cysteine proteinase inhibitor (ab146608)
Key features and details
- Potent, cell-permeable cysteine proteinase inhibitor
- CAS Number: 110044-82-1
- Purity: > 95%
- Supplied in DMSO (10 mM)
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
ALLN (DMSO solution), cysteine proteinase inhibitor -
Description
Potent, cell-permeable cysteine proteinase inhibitor -
Biological description
Potent, cell-permeable cysteine proteinase inhibitor (Ki values are 190 (calpain I), 220 (calpain II), 150 (cathepsin B) nM and 500 pM (cathepsin L). Promotes Bax-dependent apoptosis in cancer cells. Antitumor agent. Active in vivo and in vitro.
Also available as a solid (ab141445). -
Purity
> 95% -
CAS Number
110044-82-1 -
Chemical structure
Properties
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Molecular weight
383.53 -
Molecular formula
C20H37N3O4 -
Sequence
LLX (Modifications: N-terminal acetyl; C-terminal aldehyde; X-1 = Nle) -
PubChem identifier
443118 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Supplied in DMSO (10 mM) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCCC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)C -
Source
Synthetic
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Research areas