CI-994, HDAC inhibitor. Cell-permeable. (ab142098)
Key features and details
- Potent, selective HDAC inhibitor. Cell-permeable.
- CAS Number: 112522-64-2
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
CI-994, HDAC inhibitor. Cell-permeable. -
Description
Potent, selective HDAC inhibitor. Cell-permeable. -
Biological description
Potent, selective HDAC inhibitor (Ki values are 0.41 (HDAC1), 0.75 (HDAC3), 100 (HDAC6), and 100 (HDAC8) μM respectively). Induces histone H3 hyperacetylation, cell differentiation and apoptosis. Inhibits proliferation and modulates G1 cell cycle arrest. Antitumor agent. Active in vivo and in vitro. Orally active. Blood-brain barrier and cell-permeable. -
Purity
> 99% -
CAS Number
112522-64-2 -
Chemical structure
Properties
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Chemical name
4-Acetamido-N-(2-aminophenyl)benzamide -
Molecular weight
269.30 -
Molecular formula
C15H15N3O2 -
PubChem identifier
2746 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC=C2N -
Source
Synthetic
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Research areas