CAY10574, Cdk9 kinase inhibitor (ab144423)
Key features and details
- Potent, selective Cdk9 kinase inhibitor
- CAS Number: 140651-18-9
- Purity: > 95%
- Soluble in DMSO
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
CAY10574, Cdk9 kinase inhibitor -
Description
Potent, selective Cdk9 kinase inhibitor -
Biological description
Potent, selective Cdk9 kinase inhibitor (IC50 = 350 nM). Moderate ATP-competitive Cdk2-cyclin E inhibitor (IC50 = 20 µM). Induces cell cycle arrest, decreasing S-phase. Shows antiproliferative effects (IC50 values are 33, 49, 64 and 62 μM for MCF7, HOS, G361, and K562 cells respectively). -
Purity
> 95% -
CAS Number
140651-18-9 -
Chemical structure
Properties
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Chemical name
4-[(E)-(3,5-Diamino-1H-pyrazol-4-yl)diazenyl]phenol -
Molecular weight
218.20 -
Molecular formula
C9H10N6O -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Nc2nnc(N)c2/N=N/c1ccc(O)cc1 -
Source
Synthetic
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Research areas