QVD-OPh (DMSO solution), caspase inhibitor (ab146605)
Key features and details
- Potent, cell-permeable, irreversible broad-spectrum caspase inhibitor
- CAS Number: 1135695-98-5
- Purity: > 95%
- Supplied in DMSO (10 mM)
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
QVD-OPh (DMSO solution), caspase inhibitor -
Description
Potent, cell-permeable, irreversible broad-spectrum caspase inhibitor -
Biological description
Potent, cell-permeable, irreversible broad-spectrum caspase inhibitor (IC50 values are 25, 50, 100 and 430 nM for caspase-3, 1, 8 and 9 respectively). Inhibits apoptosis. Shows anti-ischemic and neuroprotective effects in vivo. Blood-brain barrier permeable.
Also available as a solid (ab141421). -
Purity
> 95% -
CAS Number
1135695-98-5 -
Chemical structure
Properties
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Molecular weight
513.49 -
Molecular formula
C26H25F2N3O6 -
Sequence
VD (Modifications: N-terminal quinolyl; C-terminal OPh) -
PubChem identifier
11237609 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Supplied in DMSO (10 mM) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)C(C(=O)NC(CC(=O)O)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C2=NC3=CC=CC=C3C=C2 -
Source
Synthetic
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Research areas