Bisindolylmaleimide XI hydrochloride, PKC inhibitor (ab143783)
Key features and details
- Potent, selective, cell-permeable protein kinase C (PKC) inhibitor
- CAS Number: 145333-02-4
- Purity: > 98%
- Soluble in DMSO to 10 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Bisindolylmaleimide XI hydrochloride, PKC inhibitor -
Description
Potent, selective, cell-permeable protein kinase C (PKC) inhibitor -
Alternative names
- BIM XI
- Ro 32-0432
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Biological description
Selective, cell-
permeable protein kinase C (PKC) inhibitor that displays 10- fold greater selectivity for PKCα (IC50 = 9 nM) and 4- fold greater selectivity for PKCβI (IC50 = 28 nM) over Ca2+- independent PKCε (IC50 = 108 nM). Enhances cardiac contractility and protection from heart failure. Prevents T- cell activation and proliferation (IC50s ranging from 30- 150 nM) associated with chronic inflammatory responses in vivo. Also inhibits GRK2, GRK5, and GRK6 (IC50 values are 29, 3.6, and 16 µM, respectively). -
Purity
> 98% -
CAS Number
145333-02-4 -
Chemical structure
Properties
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Chemical name
3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride -
Molecular weight
489.01 -
Molecular formula
C28H28N4O2.HCl -
PubChem identifier
11605551 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 10 mM (with warming) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C5CC(CCN5C6=CC=CC=C64)CN(C)C.Cl -
Source
Synthetic
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Research areas
