Bisindolylmaleimide II, PKC inhibitor (ab144206)
Key features and details
- Potent, selective ATP-competitive PKC inhibitor. Potent noncompetitive nAChR antagonist.
- CAS Number: 137592-45-1
- Purity: > 97%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Bisindolylmaleimide II, PKC inhibitor -
Description
Potent, selective ATP-competitive PKC inhibitor. Potent noncompetitive nAChR antagonist. -
Biological description
Potent, selective ATP-competitive PKC inhibitor (IC50 values are 0.01, 0.75 and 2 μM for PKC, phosphorylase kinase and PKA respectively). Potent noncompetitive nAChR antagonist (IC50 = 0.03 μM, catecholamine secretion in nicotine-stimulated PC-12 cells). Shows more potent antinicotinic effects than Bisindolylmaleimide IV (ab144208) and V (ab144205). Induces apoptosis and shows antiproliferative effects. -
Purity
> 97% -
CAS Number
137592-45-1 -
Chemical structure
Properties
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Chemical name
3-(1H-Indol-3-yl)-4-[1-[2-(1-methylpyrrolidin-2-yl)ethyl]indol-3-yl]pyrrole-2,5-dione -
Molecular weight
438.52 -
Molecular formula
C27H26N4O2 -
PubChem identifier
2397 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1CCCC1CCN2C=C(C3=CC=CC=C32)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65 -
Source
Synthetic
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Research areas