BAY 11-7085, Irreversible inhibitor of TNF alpha-induced IxBalpha phosphorylation (ab141574)
Key features and details
- Irreversible inhibitor of TNF-α-induced IxBα phosphorylation
- CAS Number: 196309-76-9
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
BAY 11-7085, Irreversible inhibitor of TNF alpha-induced IxBalpha phosphorylation -
Description
Irreversible inhibitor of TNF-α-induced IxBα phosphorylation -
Biological description
Irreversibly inhibits TNF-α-induced IxBα phosphorylation. Reduces NF-κB and adhesion molecules (IC50 = 5-10 μM). Anti-inflammatory, anti cancer and neuroprotective agent in vivo. -
Purity
> 99% -
CAS Number
196309-76-9 -
Chemical structure
Properties
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Chemical name
(E)-3-(4-tert-Butylphenyl)sulfonylprop-2-enenitrile -
Molecular weight
249.30 -
Molecular formula
C13H15NO2S -
PubChem identifier
5353432 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)C=CC#N -
Source
Synthetic
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Research areas