Anti-Tyrosinase antibody [T311] (ab738)
Key features and details
- Mouse monoclonal [T311] to Tyrosinase
- Reacts with: Human
- Isotype: IgG2a
Overview
-
Product name
Anti-Tyrosinase antibody [T311]
See all Tyrosinase primary antibodies -
Description
Mouse monoclonal [T311] to Tyrosinase -
Host species
Mouse -
Specificity
Studies have shown tyrosinase to be a very specific marker for melanomas, not cross reacting with any other tumors or normal tissues tested Other studies have shown tyrosinase to be a more sensitive marker when compared to HMB-45 and MART-1. It has also shown to label a higher percentage of desmoplastic melanomas than HMB-45. However, both tyrosinase and MART-1 negative staining was seen in those variants without an epidermal component. Unlike HMB-45, neither tyrosinase or MART-1 discriminates between activated or resting melanocytes. In conclusion, tyrosinase appears to be a superior melanoma marker when compared to HMB-45. -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant full length protein.
-
Positive control
- Melanoma
-
General notes
This product was changed from ascites to tissue culture supernatant on [20/07/17]. The following lots are from ascites and are still in stock as of [20/07/17] – [GR278593]. Lot numbers higher than [GR278593] will be from tissue culture supernatant. Please note that the dilutions may need to be adjusted accordingly.
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.099% Sodium azide
Constituents: 0.9% Proprietary component, 99% Water -
Concentration information loading... -
Purity
Tissue culture supernatant -
Clonality
Monoclonal -
Clone number
T311 -
Myeloma
unknown -
Isotype
IgG2a -
Light chain type
kappa -
Research areas
