Antibodies, Proteins, Kits and Reagents for Life Science

274 732 ₸ Product size

100 µg 274 732 ₸

Order now and get it on Wednesday March 03, 2021

Key features and details

Product name

Anti-TFPI antibody
See all TFPI primary antibodies
Description

Rabbit polyclonal to TFPI
Host species

Rabbit
Tested Applications & Species

Application Species
WB
Human

See all applications and species data
Immunogen

Synthetic peptide corresponding to Human TFPI aa 1-100 conjugated to keyhole limpet haemocyanin.
(Peptide available as ab66543)

Form

Liquid
Storage instructions

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage buffer

pH: 7.40
Preservative: 0.02% Sodium azide
Constituent: PBS

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Purity

Immunogen affinity purified
Clonality

Polyclonal
Isotype

IgG
Research areas

Our Abpromise guarantee covers the use of ab66544 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application	Species
WB	Human
All applications	Rat Cow Chimpanzee Rhesus monkey Orangutan

Application	Abreviews	Notes
WB		Use a concentration of 1 µg/ml. Detects a band of approximately 52 kDa (predicted molecular weight: 35 kDa).

Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 52 kDa (predicted molecular weight: 35 kDa).

Function

Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
Tissue specificity

Mostly in endothelial cells.
Sequence similarities

Contains 3 BPTI/Kunitz inhibitor domains.
Domain

This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa.
Post-translational
modifications

O-glycosylated.
Cellular localization

Secreted.
Target information above from: UniProt accession P10646 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
Database links
- Entrez Gene: 7035 Human
- Entrez Gene: 29436 Rat
- Entrez Gene: 613026 Rhesus monkey
- Omim: 152310 Human
- SwissProt: P10646 Human
- SwissProt: Q02445 Rat
- SwissProt: Q28864 Rhesus monkey
- Unigene: 516578 Human
- Unigene: 15795 Rat
see all
Alternative names
- Anti convertin antibody
- EPI antibody
- Extrinsic pathway inhibitor antibody
- LACI antibody
- Lipoprotein associated coagulation inhibitor antibody
- Lipoprotein-associated coagulation inhibitor antibody
- TFI antibody
- TFPI 1 antibody
- TFPI antibody
- TFPI1 antibody
- TFPI1_HUMAN antibody
- Tissue factor pathway inhibitor (lipoprotein associated coagulation inhibitor) antibody
- Tissue factor pathway inhibitor antibody
see all

Publishing research using ab66544? Please let us know so that we can cite the reference in this datasheet.

ab66544 has been referenced in 2 publications.

Cheng X et al. Trimethylamine N-oxide promotes tissue factor expression and activity in vascular endothelial cells: A new link between trimethylamine N-oxide and atherosclerotic thrombosis. Thromb Res 177:110-116 (2019). PubMed: 30875490
Liczko J et al. Tissue factor and tissue factor pathway inhibitor in chronically inflamed gallbladder mucosa. Biomed Res Int 2014:403639 (2014). IHC-Fr ; Human . PubMed: 24716194