Antibodies, Proteins, Kits and Reagents for Life Science

268 032 ₸ Product size

100 µg 268 032 ₸

Order now and get it on Thursday February 25, 2021

Key features and details

Product name

Anti-HuR / ELAVL1 antibody
See all HuR / ELAVL1 primary antibodies
Description

Rabbit polyclonal to HuR / ELAVL1
Host species

Rabbit
Tested Applications & Species

Application Species
WB
Human

See all applications and species data
Immunogen

Synthetic peptide corresponding to Human HuR/ ELAVL1 aa 1-100 conjugated to keyhole limpet haemocyanin.
(Peptide available as ab28843)

Form

Liquid
Storage instructions

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage buffer

pH: 7.40
Preservative: 0.02% Sodium azide
Constituent: PBS

Batches of this product that have a concentration
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Purity

Immunogen affinity purified
Clonality

Polyclonal
Isotype

IgG
Research areas

Our Abpromise guarantee covers the use of ab28660 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application	Species
WB	Human
All applications	Mouse Chicken Cow

Application	Abreviews	Notes
WB	(1)	Use a concentration of 1 µg/ml. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa). Another band of approximately 52 kDa is also detected, we are unsure as the identity of this band.

Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa). Another band of approximately 52 kDa is also detected, we are unsure as the identity of this band.

Function

Involved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs.
Tissue specificity

Ubiquitous.
Sequence similarities

Belongs to the RRM elav family.
Contains 3 RRM (RNA recognition motif) domains.
Post-translational
modifications

Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge.
Cellular localization

Cytoplasm.
Target information above from: UniProt accession Q15717 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
Database links
- Entrez Gene: 1994 Human
- Entrez Gene: 15568 Mouse
- Omim: 603466 Human
- SwissProt: Q15717 Human
- SwissProt: P70372 Mouse
- Unigene: 184492 Human
- Unigene: 713744 Human
- Unigene: 119162 Mouse
Alternative names
- ELAV (embryonic lethal abnormal vision Drosophila) like 1 antibody
- ELAV (embryonic lethal, abnormal vision, Drosophila) like 1 (Hu antigen R) antibody
- ELAV like 1 antibody
- ELAV like RNA binding protein 1 antibody
- ELAV-like protein 1 antibody
- ELAV1 antibody
- ELAV1_HUMAN antibody
- Elavl1 antibody
- Embryonic lethal abnormal vision drosophila homolog like 1 antibody
- Hu Antigen R antibody
- Hu-antigen R antibody
- Hua antibody
- HuR antibody
- MelG antibody
see all

Publishing research using ab28660? Please let us know so that we can cite the reference in this datasheet.

ab28660 has been referenced in 3 publications.

Green LC et al. Human antigen R as a therapeutic target in pathological cardiac hypertrophy. JCI Insight 4:N/A (2019). PubMed: 30668549
Wang F et al. The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis. Cell Res 27:416-439 (2017). PubMed: 28244490
Workman E et al. U1A regulates 3' processing of the survival motor neuron mRNA. J Biol Chem 289:3703-12 (2014). PubMed: 24362020