Antibodies, Proteins, Kits and Reagents for Life Science

247 929 ₸ Product size

100 µg 247 929 ₸ 100 µg 247 929 ₸

Order now and get it on Thursday February 25, 2021

Key features and details

Product name

Anti-DEK antibody
See all DEK primary antibodies
Description

Rabbit polyclonal to DEK
Host species

Rabbit
Tested Applications & Species

Application Species
WB
Human

See all applications and species data
Immunogen

Synthetic peptide corresponding to Human DEK aa 50-150 conjugated to keyhole limpet haemocyanin.
(Peptide available as ab116620)
Positive control
- This antibody gave a positive signal in Human brain tissue lysate.

Form

Liquid
Storage instructions

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage buffer

pH: 7.40
Preservative: 0.02% Sodium azide
Constituent: PBS

Batches of this product that have a concentration
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Purity

Immunogen affinity purified
Clonality

Polyclonal
Isotype

IgG
Research areas

Our Abpromise guarantee covers the use of ab105175 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application	Species
WB	Human
All applications	Rat Horse Cow Dog Pig Macaque monkey

Application	Abreviews	Notes
WB		Use a concentration of 1 µg/ml. Detects a band of approximately 43 kDa (predicted molecular weight: 43 kDa).

Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 43 kDa (predicted molecular weight: 43 kDa).

Function

Involved in chromatin organization.
Tissue specificity

Ubiquitous. Expressed at relatively high levels.
Involvement in disease

A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK-NUP214 fusion gene (PubMed:1549122).
Sequence similarities

Contains 1 SAP domain.
Post-translational
modifications

Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase, and weakens the binding of DEK to DNA.
Cellular localization

Nucleus. Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.
Target information above from: UniProt accession P35659 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
Database links
- Entrez Gene: 7913 Human
- Entrez Gene: 306817 Rat
- Omim: 125264 Human
- SwissProt: P35659 Human
- SwissProt: Q6AXS3 Rat
- Unigene: 484813 Human
- Unigene: 25099 Rat
Alternative names
- D6S231E antibody
- Dek antibody
- DEK gene antibody
- DEK oncogene antibody
- DEK oncogene DNA binding antibody
- DEK_HUMAN antibody
- Protein DEK antibody
see all

Publishing research using ab105175? Please let us know so that we can cite the reference in this datasheet.

ab105175 has not yet been referenced specifically in any publications.