Amlodipine besylate, L-type calcium channel blocker (ab141777)
Key features and details
- Potent L-type calcium channel blocker
- CAS Number: 111470-99-6
- Purity: > 99%
- Soluble in water to 10 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Amlodipine besylate, L-type calcium channel blocker -
Description
Potent L-type calcium channel blocker -
Biological description
Potent L-type calcium channel blocker. Inhibits Ca2+induced contractions (IC50 = 2 nM). Shows antiproliferative effects. Shows antihypertensive effects in vivo. Orally active. -
Purity
> 99% -
CAS Number
111470-99-6 -
Chemical structure
Properties
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Chemical name
3-O-Ethyl 5-O-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate benzenesulfonic acid -
Molecular weight
567.10 -
Molecular formula
C20H25ClN2O5.C6H6O3S -
PubChem identifier
60496 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 10 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O -
Source
Synthetic
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Research areas
Images
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Functional Studies - Amlodipine besylate, L-type calcium channel blocker (ab141777)Amlodipine besylate blocks L-type Ca2+ currents in Xenopusoocytes.
A. Time course of L-type channel (CaV1.2+a2d1+ß1a) activity before and during applications of 100 µM Amlodipine besylate (ab141777; green) and upon wash. Holding potential was -100 mV and currents were elicited every 10 seconds by 100 ms steps to 0 mV.
B. Example current traces before (black) and during application of 100 µM Amlodipine besylate (taken from the experiment described in A).