AM251, CB1 receptor antagonist / inverse agonist (ab120088)
Key features and details
- CB1 receptor antagonist / inverse agonist
- CAS Number: 183232-66-8
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AM251, CB1 receptor antagonist / inverse agonist -
Description
CB1 receptor antagonist / inverse agonist -
Biological description
Cannabinoid CB1 receptor antagonist / inverse agonist (Ki = 7.5 nM). Displays 306-fold selectivity over CB2 receptors. Anorectic and antidepressant in vivo.
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Purity
> 99% -
CAS Number
183232-66-8 -
Chemical structure
Properties
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Chemical name
1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide -
Molecular weight
555.24 -
Molecular formula
C22H21Cl2IN4O -
PubChem identifier
2125 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(NN1CCCCC1)c4nn(c2ccc(Cl)cc2Cl)c(c3ccc(I)cc3)c4C -
Source
Synthetic
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Research areas
