(+)-JQ1 (DMSO solution), BET bromodomain inhibitor (ab146612)
Key features and details
- Potent, selective and cell-permeable BET bromodomain inhibitor
- CAS Number: 1268524-70-4
- Purity: > 99%
- Supplied in DMSO (10mM)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
(+)-JQ1 (DMSO solution), BET bromodomain inhibitor -
Description
Potent, selective and cell-permeable BET bromodomain inhibitor -
Alternative names
- (S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
- 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)
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Purity
> 99% -
CAS Number
1268524-70-4 -
Chemical structure
Properties
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Chemical name
(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid tert-butyl ester -
Molecular weight
456.99 -
Molecular formula
C23H25ClN4O2S -
PubChem identifier
46907787 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Supplied in DMSO (10mM) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C -
Source
Synthetic
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Research areas
- Cell Biology
- Proteolysis / Ubiquitin
- Proteasome / Ubiquitin
- Ubiquitin E3 Enzymes
- RING Finger E3 Ligase
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Co-activators/co-repressors
