Pentostatin, adenosine deaminase inhibitor (ab218602)
Key features and details
- Potent, irreversible, cell-permeable adenosine deaminase inhibitor
- CAS Number: 53910-25-1
- Soluble in water to 100 mM and in DMSO to 75 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Pentostatin, adenosine deaminase inhibitor -
Description
Potent, irreversible, cell-permeable adenosine deaminase inhibitor -
Alternative names
- 2’-Deoxycoformycin
- CI 825
- CL 67310465
see all -
Biological description
Potent, irreversible, cell-permeable adenosine deaminase inhibitor (Ki = 0.9 pM) which interrupts DNA synthesis in dividing cells. Purine analog reported to exert selective toxicity towards lymphocytes. Anticancer agent.
-
CAS Number
53910-25-1 -
Chemical structure
Properties
-
Chemical name
(8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol -
Molecular weight
268.27 -
Molecular formula
C11H16N4O4 -
PubChem identifier
439693 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in water to 100 mM and in DMSO to 75 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2NC=NC[C@H]3O)CO)O -
Source
Synthetic
-
Research areas
