AICAR (Acadesine/AICA riboside) (aqueous solution), protein kinase activator (ab146594)
Key features and details
- Cell-permeable activator of AMP-activated protein kinase
- CAS Number: 2627-69-2
- Purity: > 98%
- Supplied in water (250 mM)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AICAR (Acadesine/AICA riboside) (aqueous solution), protein kinase activator -
Description
Cell-permeable activator of AMP-activated protein kinase -
Biological description
Cell-permeable activator of AMP-activated protein kinase. Is taken up into cells by adenosine transporters and phosphorylated by adenosine kinase to the active nucleotide ZMP (5-aminoimidazole-4-carboxamide ribonucleoside), which mimics effects of AMP on the AMPK system. Active in vivo and in vitro.
Also available as a solid (ab120358). -
Purity
> 98% -
CAS Number
2627-69-2 -
Chemical structure
Properties
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Chemical name
5-Amino-1-[(2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl]-1H-imidazole-4-carboxamide -
Molecular weight
258.23 -
Molecular formula
C9H14N4O5 -
PubChem identifier
17513 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Supplied in water (250 mM) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
NC(=O)c2ncn([C@@H]1O[C@H](CO)[C@H](O)[C@@H]1O)c2N -
Source
Synthetic
