AG 825, ErbB2 inhibitor (ab145566)
Key features and details
- Selective ErbB2 inhibitor
- CAS Number: 149092-50-2
- Purity: > 96%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AG 825, ErbB2 inhibitor -
Description
Selective ErbB2 inhibitor -
Biological description
Selective ErbB2 inhibitor (IC50 values are 0.15 and 19 μM at ErbB2 and ErbB1, respectively). Suppresses IL-6 induced STAT3 activation. Shows antiproliferative effects. Shows antitumor effects in vivo.
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Purity
> 96% -
CAS Number
149092-50-2 -
Chemical structure
Properties
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Chemical name
3-[3-[(2-Benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-2-propenamide -
Molecular weight
397.47 -
Molecular formula
C19H15N3O3S2 -
PubChem identifier
6091659 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=CC(=CC(=C1O)CSC2=NC3=CC=CC=C3S2)C=C(C#N)C(=O)N -
Source
Synthetic
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Research areas