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Neuroscience Neurotransmission Receptors / Channels Ligand-Gated Ion Channels NMDA Receptors

AG 555 (Tyrphostin B46), EGFR-tyrosine kinase inhibitor (ab145877)

Key features and details

  • Potent EGFR-tyrosine kinase inhibitor
  • CAS Number: 133550-34-2
  • Purity: > 98%
  • Soluble in ethanol and in DMSO to 30 mM
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    AG 555 (Tyrphostin B46), EGFR-tyrosine kinase inhibitor
  • Description

    Potent EGFR-tyrosine kinase inhibitor
  • Alternative names

    • Tyrphostin B46
  • Biological description

    Potent EGFR-tyrosine kinase inhibitor (IC50 = 700 nM). Blocks Cdk2 activation. Active form of tyrphostin A1 (ab145235). Induces cell arrest at late G1 phase (IC50 values are 6.4 and 9.4 μM for HPV16-immortalized and normal keratinocytes respectively). Shows similar effects to AG 556 (ab145878).
  • Purity

    > 98%
  • CAS Number

    133550-34-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)prop-2-enamide
  • Molecular weight

    322.36
  • Molecular formula

    C19H18N2O3
  • PubChem identifier

    5328770
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol and in DMSO to 30 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C(C=C1)CCCNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N
  • Source

    Synthetic

  • Research areas

    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • Ligand-Gated Ion Channels
    • NMDA Receptors
    • Signal Transduction
    • Protein Phosphorylation
    • Tyrosine Kinases
    • Receptor Tyrosine Kinases
    • Signal Transduction
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    • EGF
    • Cell Biology
    • Cell Cycle
    • Cell differentiation
    • Neuroscience
    • Sensory System
    • Somatosensory system
    • Nociception
    • Neuroscience
    • Neurology process
    • Neurodegenerative disease
    • Other
    • Cancer
    • Growth factors
    • EGF
    • Cancer
    • Signal transduction
    • Protein phosphorylation
    • Tyrosine kinases
    • Receptor tyrosine kinases
    • Cancer
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    • Biochemicals
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    • Tyrosine Kinase
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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