Ac-SAHA, Derivative of SAHA (ab146923)
Key features and details
- Derivative of SAHA; Caged HDAC inhibitor.
- Purity: > 98%
Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ac-SAHA, Derivative of SAHA -
Description
Derivative of SAHA; Caged HDAC inhibitor. -
Biological description
(7-diethylaminocoumarin-4-yl)methyl ester derivative of SAHA (suberoylanilide hydroxamic acid), a potent non-selective histone deacetylase (HDAC) inhibitor. Caged HDAC inhibitor, which releases SAHA upon cleavage of the photolabile (7-diethylaminocoumarin-4-yl)methyl protecting group in response to photoirradiation. Shows essentially no HDAC-inhibitory activity prior to photoirradiation.
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Purity
> 98% -
Chemical structure
Properties
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Chemical name
N-{[7-(Diethylamino)-2-oxo-2H-chromen-4-yl]methoxy}-N'-phenyloctanediamide
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Molecular weight
493.60 -
Molecular formula
C28H35N3O5 -
Storage instructions
Store at +4°C. Store In the Dark. -
Solubility overview
Soluble in DMSO to 100 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCN(CC)c1ccc3c(c1)OC(=O)C=C3CONC(=O)CCCCCCC(=O)Nc2ccccc2 -
Source
Synthetic
