A-3 hydrochloride, PKA, PKG, Casein Kinase I and II inhibitor (ab143761)
Key features and details
- Inhibits cAMP and cGMP dependent protein kinases. Also inhibits MLC kinase, casein kinase I and II and protein kinase C.
- CAS Number: 78957-85-4
- DMSO, water
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
A-3 hydrochloride, PKA, PKG, Casein Kinase I and II inhibitor -
Description
Inhibits cAMP and cGMP dependent protein kinases. Also inhibits MLC kinase, casein kinase I and II and protein kinase C. -
Alternative names
- A-3
- N-(2-Aminoethyl)-5-chloro-1-naphthalenesulfonamide, Hydrochloride
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Biological description
Competitive inhibitor with respect to ATP of PKA (cAMP-dependent protein kinase) and cGMP-dependent protein kinase, PKC (protein kinase C), casein kinase I and II, and MLCK (myosin light chain kinase) (Ki = 7.4μM).
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CAS Number
78957-85-4 -
Chemical structure
Properties
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Chemical name
N-(2-Aminoethyl)-5-chloro-1-naphthalenesulfonamide hydrochloride -
Molecular weight
321.22 -
Molecular formula
C12H13CN2O2S.HCl -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
DMSO, water -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
