8-Hydroxy-2'-deoxyguanosine, Oxidative stress biomarker (ab145595)
Key features and details
- Oxidative stress biomarker
- CAS Number: 88847-89-6
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
8-Hydroxy-2'-deoxyguanosine, Oxidative stress biomarker -
Description
Oxidative stress biomarker -
Biological description
Oxidative stress biomarker. A predominant form of free radical-induced oxidative lesions in nuclear and mitochondrial DNA. Oxidized deoxyguanosine derivative. Biomarker for oxidative stress and carcinogenesis. -
Purity
> 98% -
CAS Number
88847-89-6 -
Chemical structure
Properties
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Chemical name
2-Amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione -
Molecular weight
283.24 -
Molecular formula
C10H13N5O5 -
PubChem identifier
73318 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1[C@@H]([C@H](O[C@H]1N2C3=C(C(=O)N=C(N3)N)NC2=O)CO)O -
Source
Synthetic
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Research areas
Images
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Functional Studies - 8-Hydroxy-2'-deoxyguanosine, Oxidative stress biomarker (ab145595) Zhang et al PLoS One. 2014 Aug 27;9(8):e105994. doi: 10.1371/journal.pone.0105994. eCollection 2014. Fig 4. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/
Pimonidazole staining and 8-Hydroxy-2'-deoxyguanosine expression in xenograft tumors.
A, Hypoxia was detected in 2 mm (a), 5 mm (b), 10 mm (c) and 15 mm (d) tumors by pimonidazole staining.